Treatment of breast cancer adhere to the “endocrine” treatment

Respondents Expert: Su Fung-tin, Second Affiliated Hospital of Sun Yat-sen, director of Breast Cancer Center, Professor, Chief Physician, Ph.D., instructor, Guangdong Medical Association, director of Breast Diseases, a member of China’s millions of women breast screening project, chief expert in Guangdong Province, Guangzhou, breast carcinoma of the professional committee chairman, Professional Committee of Chinese Anti-Cancer Association, breast cancer, a member of the Guangdong Association of Breast Cancer Professional Committee of the Standing Committee.

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Surgery alone can not completely solve the problem

The status of breast cancer recurrence is worrying. Experts said that at present, breast cancer recurrence rate as high as 40% or more! Second Affiliated Hospital of Sun Yat-sen, director of breast cancer, said Professor Su Fengxi recurrence led to death of the main causes of breast cancer patients. Related information: occurrence of bone metastases 5-year survival rate of only 16% of the 5-year survival rate of lung metastasis was only 12%, while the 5-year survival rate of liver metastasis or even zero.

Breast cancer treatment must be standardized

Awareness of breast cancer in many patients there is a misunderstanding that the treatment of breast cancer is a simple surgical treatment, as long as the cut was clean, they will not relapse. Professor Su Fengxi said: “The breast cancer treatment must be standardized, simple surgery can not completely solve the problem. Must be dominated by specialist teams develop individualized treatment programs, including through surgery, chemotherapy, radiotherapy, endocrine therapy and so on means of a combination treatment. ”

Endocrine therapy should persist for at least 5 years

It is understood that, Zhongshan Hospital 2 Cancer Center Breast-conserving surgery has always been Paul armpit to stay ahead in the country reached the international level. Professor Su Fengxi said that determine the level of surgical resection was complete or not, but the key is to reduce the risk of recurrence is individualized treatment. Individualized treatment is aimed at the physiological and pathological characteristics of patients, selected to develop the most effective and the most reasonable treatment.

Professor Su said that compared to other tumors, breast cancer is its most prominent feature of the occurrence and development and in vivo levels of estrogen and its metabolism. For the estrogen and progesterone receptor-positive, particularly in response to a high positive patients, endocrine therapy is to reduce the risk of relapse and the most effective means. The principle is that by inhibiting or reducing estrogen secretion, and reduce estrogen levels or block the pathways, thus choking off the tumor’s survival, “nutrient” source.

Related data show that more than half of patients with breast cancer are hormone receptor-positive patients, so the implementation of endocrine therapy is still relatively common. Because breast cancer recurrence after 5 years are the peak period, therefore, should insist on five years of hormonal therapy, some patients need to adhere to a longer time.

Patients should choose a suitable drug

According to reports, the current endocrine therapy are mainly two types of Tamoxifen and aromatase inhibitors. In recent years, for postmenopausal hormone receptor-positive early breast cancer patients in order to Arimidex (Anastrozole), represented by the third-generation aromatase inhibitors as adjuvant endocrine therapy for standard programs, on the basis of tamoxifen to further reduce the risk of recurrence by 24%. ATAC100 experimental data show that compared with tamoxifen, the use of anastrozole in patients with a significant reduction in risk of relapse 24%, significantly reducing the risk of distant metastasis 16%, significantly reducing the risk of contralateral breast cancer by 40%.

Treatment of breast cancer must be sustained

In order to improve patient treatment and lifelong follow-up of breast cancer awareness, breast cancer by the Professional Committee of Chinese Anti-Cancer Association, led the first breast cancer education and follow-up project — Kang project has been introduced this year. As Kang project publicity and popularity than ever before breast cancer follow-up rate has increased, while more standardized and is expected to establish a standardized follow-up mechanism. The project follow-up of a wide range of methods and content-rich patient education tool kit to help breast cancer patients with a correct attitude and actively cooperate with treatment, to improve the quality of life.

Finally, Professor Su Fengxi appeal to tens of millions of breast cancer patients can not be trapped in a “doctor when critically ill,” the misunderstanding, it must under the guidance of a specialist medication, insists on endocrine therapy. As long as the appropriate treatment, the patient perseverance, I breast cancer 10-year disease-free survival in patients with the opportunity to reach over 90%.