Immunization and habitual abortion are related
October 2nd, 2009
As the saying goes, “October conceive, be born.” Pregnancy, childbirth, that is also easy to easy to say difficult to be very difficult, the vast majority of pregnant women can flat-shun-shun birth, part of the pregnant women will appear miscarriage. It is generally consecutive three or more miscarriages occur, known as habitual abortion, and this often occurs in every pregnancy, abortion, the same month, study its causes are complex. In addition to chromosomal abnormalities, endocrine diseases, syphilis, mycoplasma and other intrauterine infection, uterine abnormalities, the considerable part of and immune disorders. Because the fetus is both a matrilineal genetic Also with the new genes with a male individual growth and development in the mother’s womb until birth, fetal and maternal immunization against the existence and balance. Once the mother, child immunization occurs both uncoordinated and often can cause the mother to the fetus resulting exclusion abortion.
It now appears that the following factors, with the abortion-related immune:
1, anti-phospholipid antibody positive: In autoimmune diseases, certain infections and under the influence of drugs, often can be seen antiphospholipid antibodies, often associated with middle and late abortion-related;
2, the lack of blocking antibodies: blocking antibodies to the fetus may play a protective effect, when this antibody deficiency, the fetus more susceptible to attacks mother’s miscarriage sensitized lymphocytes.
3, human leukocyte antigen (HLA): habitual abortion couples shared between the HLA antigens than the average person, and this is not conducive to stimulate the mother after conception the corresponding sufficient “blocking antibodies” to protect the fetus.
4, maternal immune imbalance: If the aid of T-lymphocytes increased inhibition of lymphocyte decline, it will cause rejection of the mother to the fetus caused by abortion.
5, maternal fetal father’s lack of anti-lymphocyte antibodies.
6, ABO blood group incompatibility. If maternal blood is O, the parent of A-or B blood-type person, there is maternal-fetal ABO blood group incompatibility may occur, causing increased miscarriage rate.
In summary, immunization and habitual abortion are closely related, and therefore habitual abortion patients in the exclusion of other causes of the cases, for diagnosis and treatment of immune factors.