Allow regeneration to deal with breast cancer, breast
February 10th, 2010
Australian scientists in a study found that in female rats found stem cells in a long become a fully functional breasts. This discovery may help scientists unravel the secrets of breast cancer recurrence, to find new ways of shaping.
In Australia, this study shows that breast cancer may be caused by an abnormal breast stem cells arise from stem cells that is difficult to kill with conventional chemotherapy. When the patient began to improve when the disease appears, will be re-discovered breast cancer cells. If the discoveries have proved applicable to humans, scientists can for abnormal breast stem cells, drug development, so that not only can eliminate tumors, cancer cells can eliminate the source of regeneration of the organization.
The long term that the use of breast stem cells can be used to grow breast tissue for breast reconstruction after mastectomy surgery, or breast augmentation surgery. The study was published in the 5 “Nature” magazine, from Melbourne Institute of Walt艾丽扎霍尔team led by Jane Weisiwade completed the second study, their first female rats from the breast Fat Lane isolated mammary stem cells.
They will one of these cells transplanted into a living female mouse breast fat years, and all of its original breast tissue removed. The regeneration of cell division, finally, in mice breasts grow in all the normal breast cells, and mammary gland function was normal, can secrete milk.
Therefore, the researchers suspect that breast stem cells in the formation of breast cancer play an important role. If the stem cells carrying a genetic defect, breasts may have breast cancer cells, gradually formed a “tumor base.” Perhaps this is seems to be successful in the conventional treatment, patients with recurrence of breast cancer also causes.
The purpose of chemotherapy is a fast separation of cancer cells, however, because the stem cells to regenerate more slowly, so more resistance. This would mean that, although the major breast cancer removed by chemical treatment, but the abnormal stem cells will continue to create cancer cells, causing tumor recurrence. Dr. Weisiwade said: “The ultimate objective is to develop drugs to effectively close the breast cancer cells. To accomplish this, the need to clearly normal and abnormal stem cells, stem cells, the precise genetic constitution. And then develop a drug-confrontational contact with stem cells , medium, and its shortcomings. “At present, the research team is examining the organization of human breast tumors to determine whether and Nazhi human lab rat has the same characteristics.